The Effect of Taurine on Myocardial Local Angiotensin II and Collagen Concentration in Renovascular Hypertensive Rats

Objective To study the protective effect of taurine on myocardial local angiotensin Ⅱ(Ang Ⅱ)and collagen concentration in renovascular hypertensive rats,and to research the mechanism of left ventricle hypertrophy.Methods Two kidney 1 clip (2K1C) rats were used to reestablish the model of renovascular hypertension.The myo cardial local Ang Ⅱconcentration (MAC) was measured by radioimmunoassay.The myocardial collagen concentration (MCC) was measured by biochemical method.The myocardial tissue structure was observed under the microscope,and the myocardial fiber diamension (MFD) was measured with micrometer.The linear correlation between MCC,MFD and MAC were analysed.Results Compared with sham operated rats,the MCC and MFD were significantly increased in 2K1C rats (P0.01),both of which positively correlated with MAC(r=0.8323,0.83513,P0.01).Taurine have an obvious suppressive effect on SBP,LVW/BW,MAC,MCC, MFD(P0.001 for all these indices), myocardial cell hypertrophy and myocardial collagenous fiber productive reaction in 2K1C rats.Conclusion The myocardial local Ang Ⅱ may play roles in the myocardial hypertrophy in 2K1C rats .Taurine can produce good protective effect on left ventricle hypertrophy probably by decreasing the myocardial local Ang Ⅱ concentration.