Pharmacokinetics and pharmacodynamics after oral and intravenous administration of tolcapone, a novel adjunct to Parkinson's disease therapy

Karin Jorga,Bärbel Fotteler,Peter Heizmann,Gerhard Zürcher

Pharmacokinetics and pharmacodynamics after oral and intravenous administration of tolcapone, a novel adjunct to Parkinson's disease therapy

1998

Karin Jorga
Bärbel Fotteler
Peter Heizmann
Gerhard Zürcher

Objective: To evaluate fully the pharmacokinetics and pharmacodynamics of tolcapone, a novel inhibitor of catechol-O-methyltransferase (COMT), after oral and intravenous administration.

Keywords:

Medicine
Anesthesia
Volume of distribution
Tolcapone
Parkinson's disease
Route of administration
Oral administration
Pharmacology
Catechol-O-methyl transferase
Pharmacokinetics
Clinical trial
Crossover study

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