The novel cyclopropapyrroloindole(CPI) bisalkylators bearing methoxycarbonyl and trifluoromethyl groups
1998
Abstract The novel 3-methoxycarbonyl-2-trifluoromethylcyclopropapyrroloindole (MCTFCPI) bisalkylators were synthesized and their antitumor activity was evaluated. Among these derivatives, 7f in which two MCTFCPI moieties are connected with a 5,5′-bis(2-carbonyl-1 H -indole) group, was found to exhibit more prominent cytotoxicity and antitumor activity than U-77,779 (bizelesin) ( 2 ).
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