Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing

Christina D. Camell,Jil Sander,Olga Spadaro,Aileen Lee,Kim Y. Nguyen,Allison Wing,Emily L. Goldberg,Yun-Hee Youm,Chester W. Brown,John D. Elsworth,Matthew S. Rodeheffer,Joachim L. Schultze,Vishwa Deep Dixit

Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing

2017

Christina D. Camell
Jil Sander
Olga Spadaro
Aileen Lee
Kim Y. Nguyen
Allison Wing
Emily L. Goldberg
Yun-Hee Youm
Chester W. Brown
John D. Elsworth
Matthew S. Rodeheffer
Joachim L. Schultze
Vishwa Deep Dixit

Lipolysis declines with age because NLRP3 inflammasome-activated adipose tissue macrophages reduce levels of noradrenaline by upregulating genes that control its degradation, such as GDF3 and MAOA.

Keywords:

Catecholamine catabolism
Lipolysis
Inflammasome
Ageing
Adipose tissue macrophages
Internal medicine
Endocrinology
Biology
Adipocyte
Monoamine oxidase A
Hormone-sensitive lipase
Adipose tissue
Catecholamine
Adipose triglyceride lipase

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