Genomic analysis of paired IDHwt glioblastoma (GB) to reveal recurrent alterations of MPDZ at relapse after radiotherapy and temozolomide (RTCT).

Brice Chanez,Romain Appay,Arnaud Guille,Arnaud Lagarde,José Adélaïde,Emilie Denicolai,Chantal Campello,Aurélie Tchoghandjian,Gregorio Petrirena,Carole Colin,Maryline Barrie,Nathalie Baeza-Kallee,Celine Boucard,Carine Jiguet-Jiglaire,Thomas Graillon,Isabelle Nanni-Metellus,Henry Dufour,Dominique Figarella-Branger,Olivier Chinot,Emeline Tabouret

Genomic analysis of paired IDHwt glioblastoma (GB) to reveal recurrent alterations of MPDZ at relapse after radiotherapy and temozolomide (RTCT).

2019

e13535Background: GB are highly aggressive tumors which systematically relapse. Our objective was to identify disease progression mechanisms and genomic drivers of GB treatment resistance. Methods:...

Keywords:

Glioblastoma
Temozolomide
Internal medicine
Oncology
Pathology
Radiation therapy
Medicine
treatment resistance
disease progression

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