Pneumonia severity index (PSI) at young patients and toll-like receptor 4 (TLR4) polymorphism interconnections: new diagnostic approach

Background: Innate immunity takes part in immune reactivity building for different pathogens. Different allele TLR4-variants may lead to changes in protective inflammation process during community acquired pneumonia (CAP) and increase PSI. Aim: To find out the interconnections between TLR4-polymorphism and PSI for predicting CAP-severity course at young patients. Materials and Methods: One hundred and five CAP-patients (age (34.1±0.8) years) were examined for PSI-score and TLR4 +3725G/C polymorphism variant (PCR - figure 1). Results: There were found 78 (74.3%) G/G-carriers, 24 (22.9%) G/C-carriers, 3 (2.9%) C/C-carriers among CAP-ones. Among G/G-carriers 47 (44.8%) had a mild CAP-course (PSI=50-70), 31 (29.6%) patients had a severe CAP-course (PSI=70-90). Among G/C-carriers 15 (14.3%) responders were classified as mild patients, 9 (8.6%) – as severe (p Conclusion: The practical appliance TLR4-polymorphism method has a great prognostic meaning - the C-allele appearance in TLR4 +3725G/C-polymorphism worsens CAP-course prediction by PSI-score elevation at young patients and is associated with increased risk of lethal outcomes in approximately 1.5 times.