[Metastatic hormonorefractory prostate cancer: treatment of disease progression after taxanes based chemotherapy].

IntroductionTaxanes represent the most active first-line treatment for metastatic hormone refractory prostate cancer. However, most patients progress while receiving taxanes-based treatment and require a second-line approach. The aim of the present study was to evaluate the activity and the safety of the combination of bevacizumab and taxanes in patients with metastatic, hormone refractory prostate cancer with evidence of disease progression after a previous docetaxel-based chemotherapy.MethodsTwenty patients were enrolled into the study protocol. Treatment consisted of bevacizumab (10 mg/kg) plus docetaxel (60 mg/m2) administered every three weeks. Biochemical and objective responses, progression-free survival, overall survival, and toxicity were evaluated.Results55% of patients had a PSA reduction > 50%, 10% had a PSA reduction > 25% to 49%, 10% had a PSA reduction 25%. Three patients with measurable disease had an objective response. Median pro...