Cordyceps sinensis Cs-5 improves memory and learning abilities in a dysmnesia model (684.1)

Cordyceps sinensis Cs-5, a mycelia fermentation product of Cordyceps sinensis (Cs), has shown its health benefits in modulating immune functions and enhancing sexual functions. This study was to examine the effects of Cs-5 on improving memory and learning abilities in a mouse model with memory impairment. ICR male mice (2 months) were randomized into 3 groups on the basis of the pre-study swimming latency in water maze test, and received Cs-5 at a dose of 0.5 or 1.5 g/kg, or vehicle for 60 days. The mice received intraperitoneal injection of Scopolamine Hydrobromide at a dose of 5mg/kg for memory acquisition impairment, and were tested with water maze and step-through tests to evaluate the memory and learning abilities. Compared to controls, mice received Cs-5 at a dose of 0.5 g/kg (equivalent to the human recommended dose) showed significantly shortened swimming latency in water maze test, and significantly prolonged step-through latency in step-through test (both p=0.03). In conclusion, our results indi...