Long-term results of the French randomized trial comparing neoadjuvant chemotherapy followed by surgery versus surgery alone in resectable non-small cell lung cancer.

7003 Background: To evaluate survival beyond 10 years of patients included in the French randomized trialcomparing neoadjuvant chemotherapy (CT-S) versus surgery alone (S) (initial publication: Depierre et al, J Clin Oncol 2002;20:247-53). Methods: Preoperative chemotherapy consisted of two cycles of mitomycin (6 mg/m2, day 1), ifosfamide (1.5 g/m2, days 1 to 3) and cisplatin (30 mg/m2, days 1 to 3), and two additional postoperative cycles for responding patients. Follow-up of patients by CT scan and fiberoptic bronchoscopy was scheduled for 7 years. Annual follow-up was performed thereafter and procedures were left to the investigator's discretion. Results: Three-hundred fifty-five eligible patients were randomized. Median follow-up was 13.8 years. The 10-year survival rate was 20.8% for the S arm and 29.4% for the CT-S arm (p=0.12). Multivariate analysis showed that neoadjuvant chemotherapy (HR=0.78; 95%CI= 0.61-0.99; p= 0.038), age, and the T and N status were significantly correlated with overall surv...