WA8242A1, A2 and B, novel secretory phospholipase A2 inhibitors produced by Streptomyces violaceusniger II. Biological properties

WA8242A 1 , A 2 and B, novel inhibitors of secretory phospholipase A 2 (PLA 2 ), were obtained from Streptomyces violaceusniger No. 8242. WA8242B inhibited secretory group I and II PLA 2 S in a dose-dependent manner. The mode of inhibition of group II PLA 2 by WA8242B was in competitive fashion. WA8242B inhibited group II PLA 2 -induced Prostaglandin I 2 (PGI 2 ) production by human umbilical vein endothelial cells. Furthermore, WA8242B was effective in mouse zymosan writhing model.