Biochemical markers in total intravenous anesthesia and propofol infusion syndrome: a preliminary study

OBJECTIVES: To investigate bio - chemically whether total intravenous anesthe - sia (TIVA) using propofol creates a risk for Propofol Infusion Syndrome (PRIS). PATIENTS AND METHODS: Forty patients scheduled for thyroid gland surgery were ran - domly assigned into Group T or C and premed - icated 30 min before operation. GroupT received remifentanyl hydrochloride, propofol infusion following anesthesia induction with propofol, ve - curonium bromide and intubation. Group C re - ceived remifentanyl hydrochloride infusion, 1-1.5 MAC desflurane inhalation following anesthesia induction with thiopental, vecuronium bromide and intubation. Patients were respired 50% O2- air mixture. Blood gas, potassium, lactic acid, CK-MB, myoglobin, troponin I, total carnitine, triglyceride, creatinine concentrations were de - termined before operation, at intraoperative hour-2, postoperative hour-6. RESULTS: There were no significant differ - ences between groups in potassium, lactic acid CK-MB, myoglobin, total carnitine or creatinine levels.Triglyceride level at intraoperative hour-2 increased in Group T, decreased at postopera - tive hour-6. Troponin I was higher in Group C than GroupT at intraoperative hour-2 ( p < 0.05). No asystole, bradycardia, arrhythmia, hypoten - sion or change in urine color was detected. CONCLUSIONS: The present biochemical find - ings suggest thatTIVA using propofol is safe.