Abstract WP336: Effects of ONO-8610539, an Injectable Small-Molecule Inhibitor of Blood Coagulation Factor XIa, on Rabbit Photothrombotic Stroke Model: Comparison With Tissue Plasminogen Activator

Shinya Sakimoto,Tetsuya Hagio,Yasuo Yonetomi,Takehiro Ono,Sho Kouyama,Hidenori Miyata,Tetsuya Yasuhiro,Masaru Sakai,Takashi Sasamura,Seishi Katsumata

Abstract WP336: Effects of ONO-8610539, an Injectable Small-Molecule Inhibitor of Blood Coagulation Factor XIa, on Rabbit Photothrombotic Stroke Model: Comparison With Tissue Plasminogen Activator

2019

Shinya Sakimoto
Tetsuya Hagio
Yasuo Yonetomi
Takehiro Ono
Sho Kouyama
Hidenori Miyata
Tetsuya Yasuhiro
Masaru Sakai
Takashi Sasamura
Seishi Katsumata

Introduction: Factor XI (FXI) is an important component in the intrinsic pathway of the coagulation system. FXI antisense oligonucleotide achieves antithrombotic efficacy with a low risk of bleedin...

Keywords:

Small molecule
Tissue plasminogen activator
Physical therapy
Stroke
Coagulation factor XIa
Pharmacology
Medicine
Diabetes mellitus
photothrombotic stroke
Thrombosis
Thrombolysis
Antithrombotic

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