Stereoselective synthesis of 7α- and 7β-aminocholestanol as potent fungicidal drugs

Potentially lymphotropic 7α- and 7β-aminocholestanol were stereoselectively synthesized. In vitro bioassay studies have shown that these fungicidal lipidic derivatives possess strong antifungal activity against Candida spp resistant strains to amphotericin B, 5-fluorocytosine and azoles.