Update on the pathogenesis of IgA nephropathy

IgA nephropathy is one of the most common glomerulonephritis in the world. Although the pathogenesis of IgA nephropathy is not clear yet, many studies have manifested that many factors such as environmental factors, genetic factors, and aberrantly glycosylated IgAl are involved in its pathogenesis. Currently, most studies focus on aberrantly glycosylated IgAl, lgA 1 circulating immune complexes depositing and abnormal IgAl removing. In addition, studies have found that ACE gene polymorphism especially DD genotype may be associated with the pathogenesis of IgA nephropathy. Furthermore, T lymphocytes, B lymphocytes,dendritic cells, transforming growth factor β1 and so on play an important role in the pathogenesis of lgA nephropathy. Key words: IgA nephropathy;  IgA1