Big Leaf Mahogany Seeds

Abstract Swietenia macrophylla King (Family: Meliaceae) seed has been mentioned as a potential antidiabetic agent in the folk medicine of different countries. The crude extracts of S. macrophylla seeds have been reported to attenuate diabetes and associated complications by triggering glucose utilization, PPARγ activation, inhibiting inflammation, and endorsing redox defense mechanism. Several antidiabetic phytochemicals were extracted from S. macrophylla seeds; however, swietenine has been regarded as the key phytochemical. Swietenine was found to exhibit antidiabetic effects by triggering glucose utilization, endorsing PPARγ activation, inhibiting superoxide generation, and impeding nitric oxide production. Considering these, the in silico molecular docking studies swietenine with the specific proteins have been executed, which revealed swietenine may interact with signal proteins, such as IRS-1, AMPK, PPARγ, NF-κB, and iNOS. Finally, in silico ADMET prediction revealed the drug-likeness character of swietenine. Therefore, swietenine would be a potential therapeutic agent for diabetes and associated complications in future.