VARIATIONS IN ATHEROSCLEROSIS PHENOTYPE WITHIN THE CORONARY AND PERIPHERAL VASCULAR TERRITORIES: INSIGHTS FROM INTRAVASCULAR ULTRASONOGRAPHY

Asrac Caeor: 2. Chroic CAD/Sale Ischemic Hear Disease: Cliicalreseaio Numer: 1201-214Auhors: Rishi Puri, Paul Bishop, Danielle Brennan, Kiyoko Uno, Yu Kataoka, James Harvey, Lindsay Feiten, Daniel Clair, Samir Kapadia, E. Murat Tuzcu, Stephen Nicholls, Cleveland Clinic, Cleveland, OH, USABackground: Iraascular ulrasou (IVS) has escrie he ure of coroar aherosclerosis, remoeli a calciicaio paers; each o o e associae ih plaque proressio a cliical ees. Hoeer, he srucural pheope of aherosclerosis ihi he peripher, a is relaioship ih he epressio of coroar aheroslerosis is poorl uersoo.Methods: Volumeric IVS imai as performe ihi he supericial femoral or epicarial coroar arer of 278 paies ueroi percuaeous reascularizaio i he peripheral (=70) or coroar (=208) circulaios, ere mache for ae, eer a iaeic saus. Groups ere compare ih rears o cliical characerisics, ascular imesios, aheroma ure, essel remoeli a calciicaio.Results: Mea ae as 7 ears, 37% ere female, a 0% iaeic. Boh peripheral a coroar roups ere ell mache for curre smoi saus (22.9 s 19.2%, p=0.51), hisor of smoi (58. s .3%, p=0.24), hperesio (85.5 s 82.2%, p=0.53) a slipiemia (85.5 s 85.%, p=0.99) respeciel. eripheral essels harore more eesie aherosclerosis ha he coroaries perce aheroma olume (52.0±12.4 s 41.3±8.7%, p<0.001) a oal aheroma olume ormalize for essel leh (555.2±173. s193.3±8.3 mm3, p<0.001 ). Volumes occupie he lume (520.0±21.8 s 27.1±89.2 mm3, p<0.001) a essel all (1084.0±300.4 s 40.4 mm3, p<0.001) ere reaer i he peripheral ersus coroar essels respeciel. Hoeer peripheral essels ere epasiel remoele (Remoeli Ie RI of 1.1±0.2), hereas he coroaries ere cosriciel remoele (RI 0.90±0.2, p<0.001). erceae of IVS frames ieiie ih calcium ere reaer i he peripher compare ih he coroaries (78.9±24.0 s 35.5±25.4%, p<0.001) respeciel.Conclusions: Mare ariaios i he epressio of aherosclerosis ihi ifferi ascular erriories eis. Local, errior speciic rheoloical facors are liel o iluece he epressio a aural hisor of aherosclerosis. This has implicaios for he local a ssemic reame of AD.