Combination of radiation and either cisplatin or carboplatin in the treatment of squamous cell carcinoma modelled in multicellular spheroids

Multicellular spheroids, derived from squamous cell carcinoma celline HN-1, have been used as a model to study the effects of both cisplatin and carboplatin when administered prior to, concurrently with, and after irradiation treatment. This study shows that platin compounds can potentiate radiation by different mechanisms, showing that the sequence of the two treatment modalities is important