Sulfation of Alginic Acid with Chlorosulfonic Acid in the Formamide-1,2-Dichloroethane Medium

In recent years the importance of alginic acid in various industries increased [2], but its sulfuric esters were poorly studied. The literature describes a method of alginic acid sulfation with chlorosulfonic acid in pyridine [2]. However, the presence of toxic pyridine, which is difficult to be removed, in food and drugs is inadmissible. Therefore, the aim of our study is to investigate the possibility of using the previously suggested method of dextran sulfation with chlorosulfonic acid in the 1,2-dichloroethane–formamide [3] for the sulfation of alginic acid.