Hepatic intra-arterial chemotherapy in anthracyclin-taxane- and vinorelbine-pretreated breast cancer patients

841 Background: Metastatic breast cancer is a challenge for medical oncologists and the mean survival after the neoplasm systemic diffusion is around 2 years. After the bone, the liver is the second metastatic site, and the hepatic relapse after 1–2 lines of chemotherapy is generally an incurable disease. Hepatic intra-arterial chemotherapy is a historical assessed procedure in colon-rectal liver mts, and recently Japanese experiences enlarged the regional application to mammary hepatic metastases with an interesting overall responses and a possible survival improvement. In the last 9 years, in our center we are applying a percutaneous implantation of hepatic arterial Port-a-Cath for secondary and primitive liver cancers, and recently we have extended these procedure to the non colon-rectal liver mts. Methods: From 2000 to 2002 we implanted our percutaneous arterial Port-a-Cath in 20 patients affected by more than 5 breast hepatic mts as the only site of disease diffusion. All the patients were pretreated...