The comparability of Second dose Thiopental with Lidocaine in The attenuation of Cardiovascular response to Endotracheal intubation

The present study comprised 120 patients aged 15 to 65 years who were divided into four groups each of 30 patients. Patients in each group were given 2 µg/kg fentanyl iv, 4 mg/kg thiopental for induction of anesthesia, followed by 0.5 mg/kg atracurium for muscle relaxation and a second dose of thiopental (1mg/kg in group I, 2mg/kg in group II) immediately prior to laryngoscopy and intubation, lidocaine 1.5 mg/kg (group III) or normal saline 5 ml (group IV) 2 minutes prior to larygoscopy and intubation. The heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), and rate pres-sure product (RPP) were determined before induction of anaesthesia and laryngoscopy (baseline) , and at 1min (T1), 3min(T3), 5min(T5), and 10min (T10) after laryngoscopy and intubation.