An Association of Lipid Abnormalities with High-Sensitivity C – reactive Protein (hsCRP) in Patients with Dyslipidemia: A Teaching Hospital Based Study

Background: High sensitive C-reactive protein (hs-CRP) is an acute phase protein whose levels are shown to be elevated in inflammation. Dyslipidemia & local inflammation are the two major determinants of cardiovascular disease (CVD). Atherosclerosis leads to inflammation which is triggered by dyslipidemia. Subjects and Methods: This present study we tried to find out the correlation between lipid abnormalities & hs-CRP. Sixty five subjects were selected purposively from the out-patient department of HIMS, Varanasi according to inclusion-exclusion criteria. Results: This study showed the strong and statistically significant positive correlation in between High-Sensitive C–reactive Protein (hsCRP) and Total Cholesterol with (p<0.012). Statistically significant positive correlation between High-Sensitive C–reactive Protein and Triglycerides (p<0.01). LDL-C also showed a statistically significant positive correlation with High-Sensitive C–reactive Protein (p<0.02). A statistically non-significant and weak negative correlation is seen between the serum hsCRP levels and HDL-C (p=0.38, r= -0.14). Conclusion: Patients with dyslipidemia for elevated blood hs-CRP levels may be done to identify those patients with an increased risk for future development of atherosclerosis as well as bad cardiovascular events at earlier stages so that they can changes their life style, food habit etc. to resist the further aggravation of dyslipidemic status as well as catastrophic cardiovascular events.