Pyridylmethylthio derivatives as VEGF inhibitors. Part 1
2010
Abstract Optimization from compound 4a , having intramolecular S–O nonbonded interaction, led to discover compounds 4m and 4n . They were highly active in vitro (VEGF induced HUVEC proliferation assay) and showed efficacies in three disease models in vivo (cancer, RA, AMD).
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