In vivo growth of a bioengineered internal anal sphincter: comparison of growth factors for optimization of growth and survival.
2011
Purpose
Our laboratory has developed and implanted a novel bioengineered internal anal sphincter (IAS) to treat anal incontinence. Fibroblast growth factor-2 (FGF-2) has been used in mice; however, the optimal growth factor for successful IAS implantation is unclear. This study compares several growth factors in order to optimize IAS viability and functionality.
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