Cardiovascular impairment in young adults horizontally infected with HIV-1 in childhood

Results CVI was encountered in 61 (10.23%) of 596 patients parenterally-infected with HIV-1 in childhood and 32 (16.16%) of 198 patients infected through sexual route, with statistically significant differences in the prevalence of CVI depending on the transmission route of HIV-1 (pChi2=0.02), probably being underestimated in pre-HAART era. The average age at the moment of CVI was 9.02±4.76 years in lot P vs. 41.47±12.41 years in lot S (p< 0.0001). The spectrum of CVI was dominated by arrhythmias and conduction blocks 42 patients (45.16%), dilated cardiomyopathy (DCM) 18 patients (19.35%), pulmonary arterial hypertension 17 patients (18.27%). The most common entity identified in parenterallyinfected patients in early childhood was DCM 16 patients lot P vs. 2 patients lot S (p Fischer test=0.026), found in moderate and severe immunosuppressed patients, with virological failure, often associated with respiratory disease. In sexually-infected patients diseases due to atherosclerosis prevailed 17 patients (p Fisher test<0.0001). The presence of high blood pressure in 2 young people with HIV/AIDS raises the issue of cardiovascular risk and occurrence of coronary heart disease in young patients. Although the survival rate of patients with CVI (15.21 ± 0.62 years) was similar to that of the patients without CVI (13.78 ± 0.25 years), for patients with CVI, death due to direct cardiac damage was significant: 9 patients (52.94%).