Formulation and Evaluation of Zaltoprofen Fast Disintegrating Tablet
2013
Zaltoprofen is a non-steroidal anti-inflammatory drug (NSAIDs) and has powerful inhibitory effects on acute and chronic inflammation with less adverse reactions on the gastrointestinal tract than other NSAIDs. The main objective of this study was to formulate and evaluate fast disintegrating tablets of zaltoprofen (ZPF) prepared by direct compression method using super-disintegrants with a view to enhance patient compliance. Two different super-disintegrants, such as crospovidone and sodium starch glycolate were used in different ratio (2-8% w/w). FTIR study reveals that there is no drug-excipients interaction between ZPF and excipients. The DSC/PXRD study revealed that the crystallinity of zaltoprofen was significantly reduced to amorphous. The dissolution study was carried out in pH6.8 phosphate buffer solution. It was observed that the tablets with 8% of crospovidone showed satisfactory results with disintegration time of 24sec, wetting time of 10sec and highest dissolution rate (100.89%) in 15min. It can be concluded that superdisintegrant, crospovidone showed better disintegrating time, wetting time and dissolution property than the sodium starch glycolate in the formulation of fast disintegrating tablets.
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