Acylated derivatives of 1,5-benzodiazepines.

: N-Acylated derivatives of 2-methyl-2-ethoxycarbonyl-4-phenyl-1H-tetrahydro-1,5-benzodiazepine (1) and 2-cyano-4-methyl-1H-tetrahydro-1,5-benzodiazepine (3-12) were obtained. From among compounds 3-12, compound 3 have shown a strong synergism with hexobarbital and antiserotonin and anticonvulsant activity, and compounds 5 and 7 have displayed antiserotonin properties. A strong antireserpine action, comparable with imipramine, has been found for compound 12, which also have antagonized electrogenic seizures.