Urocanic acid content of the epidermis of diabetics

A degree of a decrease in the content of urocanic acid in washes-off from the skin surface of patients with decompensated diabetes mellitus depends on a period and gravity of disease that may be indicative of disorders of the adenylate cyclase system (or one of its links). Change in the content of urocanic acid in the epidermis of patients with diabetes mellitus treated with the Biostator apparatus, correlates with change in the content of glucagon and blood sugar. The authors discuss a possibility to use the test of urocanic acid determination for the prediction and assessment of the efficacy of therapy of patients with diabetes mellitus.