Synthesis of a new bisphosphonic acid ligand (SEDP) and preparation of a 188Re-(Sn)SEDP bone seeking radiotracer

Abstract The new bisphosphonate ligand SEDP (2-sulfonato-1,1-ethylidene bisphosphonic acid) has been synthesized and characterized, including the determination of the protonation constants, and used to form 188 Re-(Sn)SEDP from Na 188 ReO 4 . The title compound 188 Re-(Sn)SEDP shows slightly greater bone uptake and less kidney uptake than 188 Re-(Sn)HEDP in rat biodistribution studies.