Dehydrobenzperidol and disopyramide in A-V conduction.

Abstract The effects on A–V conduction of dehydrobenzperidol (Droperidol) (0.35 and 1.0 mg/kg i.v.) and disopyramide (1, 5 and 10 mg/kg i.v.) were tested in anesthetized, open chest and paced dogs. His's bundle electrograms were recorded by means of a catheter electrode or by a sutured electrode-bearing plaque in the A–V nodal region. Droperidol at the lower dose did not modify conduction time, while 1.0 mg/kg (3 times the usual clinical dose), prolonged atrial—His conduction without modifying H—V interval. Disopyramide 1 mg/kg caused a nonsignificant decreased in atrial—His conduction time, while in doses of 5 and 10 mg/kg it prolonged both conduction times (S—H and H—V), due to a predominant direct depressant effect, which is opposite to the atropinic actions of the drug.