Transdermal fentanyl for the treatment of pain after major urological operations : a randomized double-blind comparison with placebo using intravenous patient-controlled analgesia

Transdermal fentanyl 75 μg/h (Fentanyl-TTS) was compared with placebo in a randomized double-blind study in the early postoperative period, using 50 patients recovering from major urological operations. Analgesic efficacy was individually titrated with intravenous fentanyl by means of a PCA pump (demand dose 34 μg, lockout time 5 min). The test systems were applied 8 h before anaesthesia and were left in situ for 24 h.