Structure elucidation of Sch 49088, a novel everninomicin antibiotic containing an unusual hydroxylamino-ether sugar, everhydroxylaminose

Abstract Degradation of Sch 49088 ( 1 ) provided a novel, highly functionalized O-substituted hydroxylamine-containing sugar, everhydroxylaminose 11 isolated as a β-OMe glycoside. Notably the two acid sensitive orthoester moieties in the intact antibiotic 1 co-exist in the presence of three phenolic groups and a free carboxylic acid group.