Phenytoin–levetiracetam adjunctive treatment-induced neurotoxicity and deregulation of cholinergic neurotransmission with evidence of neurocognitive impairment in male Wistar rats

Opeyemi Samson Osuntokun,Mary Olabisi Aderoju,Ifeoluwa Esther Adebisi,Taiwo Adekemi Abayomi,Olorunfemi Samuel Tokunbo,Gbola Olayiwola

Phenytoin–levetiracetam adjunctive treatment-induced neurotoxicity and deregulation of cholinergic neurotransmission with evidence of neurocognitive impairment in male Wistar rats

2021

Opeyemi Samson Osuntokun
Mary Olabisi Aderoju
Ifeoluwa Esther Adebisi
Taiwo Adekemi Abayomi
Olorunfemi Samuel Tokunbo
Gbola Olayiwola

The effects of chronic administration of phenytoin (PHT), levetiracetam (LEV), and PHT + LEV adjunctive treatments were examined on the cognitive functions of male rats.Twenty-eight male Wistar rat...

Keywords:

Pharmacology
Levetiracetam
Neurocognitive
Medicine
Phenytoin
cholinergic neurotransmission
Neurotoxicity
adjunctive treatment

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