NQO1C(下标 609T), RAD51(下标 G135C)和XRCC3(下标 C241T)单核苷酸多态性与急性淋巴细胞白血病发病相关性研究

This study was purposed to investigate the relationship between NQ01C(subscript 609T), RAD51(subscript G135C), XRCC3(subscript C24lT) single nucleotide polymorphisms and incidence of acute lymphoblastic leukemia (ALL). NQO1C(subscript 609T), RAD5l(subscript G135C), XRCC3(subscript C241T) genotypes were detected by PCR-RFLP in 170 patients with de novo ALL and 458 normal persons as control. The results indicated that the genotype ratio of NQO1C(subscript 609T), RAD5l(subscript G135C) and XRCC3(subscript C241T) in single genotype analysis showed no statistical difference between ALL patients and normal controls, which. suggested that the singie genotype affect onset of ALL without statistical significance. In combined genotype analysis, presence of both variants for NQO1C(subscript 609T) and RAD5l(subscript G135C) increased onset risk of ALL with myeloid antigen positive and with balanced translocation (OR value 5.553 and 2.618 respectively); the presence of homozygosity variant for NQ01C609T increased onset risk of ALL in the country-children (OR=2.541). In conclusion, the combined effect of NQO1C(subscript 609T), RAD5l(subscript G135C) and XRCC3C(subscript C241T) genotypes may promote occurence of ALL, which suggests that the combined analysis of 3 genotypes has more predictive significance for ALL than single genotype analysis.