Acrodermatitis enteropathica deficioccy with immune
1973
A male in[ant presented with alopecia, eczematoid dermatitis, chronic diarrhea, and [ailure to thrive. The usual causes o[ chronic malabsorption were ruled out. Acrodermatitis enteropathica was diagnosed. A trial o[ oral Diodoquin and breast milk as the only source o[ nutrition resulted in rapid amelioration o[ symptoms. The patient acquired secondary diarrhea and secondary injections with enteropathogenie Escherichia coli, Candida, and Pseudomonas aeruginosa and subsequently died o[ sepsis. Studies o[ serum and tears revealed a marked deficiency o[ irnmunoglobulins. Necropsy demonstrated a generalized de[eet in his immunopoietic tissues. There were low levels o[ the essential [arty acids in serum. The observations in this case suggest that acrodermatitis enteropathica may in some instances be the clinical expression o[ a primary immune disorder.
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