Complex Approach to Xenobiotics Hepatotoxicity Testing using a Microfluidic System.

We analyzed hepatotoxicity of three drugs: acetaminophen, metformin, and isoniazid. Spher- RLGVRIGLIIHUHQWLDWHG�+HSD5*�FHOOVFXOWXUHGXQGHUPLFUR?XLGLFFRQGLWLRQVZHUHXVHGDVWKH� model. Acute toxicity of substances was assessed by analyzing cell viability, while lactate concentration in the culture medium was used as the potential marker for evaluation of chronic exposure and non-lethal side effects of xenobiotics. The results were compared with mito- FKRQGULDODFWLYLW\�DQG�'1$�IUDJPHQWDWLRQGDWD��7KHHIoFLHQF\�DQGSRVVLELOLW\�RIDSSO\LQJWKH� integrated approach for assessment of drug hepatotoxicity are discussed.