Novel Polypeptides and codante for these adn.

NEW polypeptides have a sequence modified polypeptide amino acid Interleukin HUMAN 1 (TYPE - ALPHA AND TYPE - BETA, wherein said amino acid sequence is exchanged for other amino acid residues and some RESIDUAL amino acids at the NY / or TERMONO C are removed as an option. polypeptides NOT HAVE ability to induce production of prostaglandin E2 but keep OTHER ACTIVITIES BIOLOGICAL human interleukin 1 as LYMPHOCYTE ACTIVATION. are believed to be useful as medicaments.