Analysis of Drugs and Metabolites in Tissues and Other Solid Matrices

Analysis of solid matrices are typically requested to help understand drug and/or metabolites concentrations at potential sites of action or toxicology, or to perform distribution studies when radiolabel is unavailable or cannot be used. Solid samples pose additional challenges for bioanalysis in terms of preparation of homogeneous QC pools, estimation of extraction recovery, supply of control matrix, and as methods may be complex and time-consuming to perform. A short literature survey is presented together with examples of tissue assays for discovery, GLP and clinical studies.