Ribosome Decoupling Induces Apoptosis

In the present contribution, we propose that t-RNA inhibition via complementary oligomer strands against t-RNA loops upregulates apoptosis. We have developed multiple oligomers that bind to different loops of the tRNA molecule. We explore the possibility of inhibition of protein formation within the cell by means of the interaction of our pharmaceutical agent termed IMTX-7135TM with t-RNA and the interaction of ribosomes. We propose that cytosolic ribosomes are intimately linked to mitochondrial t-RNAs; thus interruption of translational processes in the cytosolic ribosomes impacts mitochondrial functionality. This current contribution sets the background hypothesis for our experimental work.