Inhibitory modulation of optogenetically identified neuron subtypes in the rostral solitary nucleus

Optogenetic identification of GABAergic and non-GABAergic (putative projection) neurons within the solitary nucleus suggests that hyperpolarization-sensitive channels impact the transfer of information across the synapse. GABAergic neurons transfer afferent information with less fidelity compared with non-GABAergic neurons; however, the fidelity of GABAergic neurons with Ih is similar to that of non-GABAergic neurons. In non-GABAergic neurons with IA, the interaction between the IA current and inhibition suppresses the transfer of information proportionally compared with non-GABAergic neurons without IA.