Epidermal growth factor receptor expression in three different human endometrial cancer cell lines.

Background. The aim of the current study was to establish the characteristics of the epidermal growth factor (EGF) receptor in endometrial cell lines to determine the possible relation of EGF to endometrial cancer. Methods. There different cell lines were used: RL95-2 (derived from a moderately differentiated adenosquamous carcinoma), HEC-I-A (from a moderately differentiated adenocarcinoma), and KLE (from a poorly differentiated adenocarcinoma). The binding of ( 125 -I) EGF to these cell lines and the stimulatory effect of EGF on ( 3 H) thymidine incorporation into DNA were examined. Results. EGF receptor was present in all there cell lines