PREPARATION OF [61CU] BLEOMYCIN COMPLEX AS A POTENLIAL PET RADIOPHARMACEUTICAL AND IT’S BIOLOGICAL EVALUATION IN NORMAL AND TUMOR-BEARING RODENTS

[Cu]Bleomycin ([Cu]BLM) was prepared using [Cu]CuCl2 produced via Zn(p,x)Cu (180μA proton irradiation, 22MeV, 3.2h), purified by ion chromatography method. [Cu]BLM was prepared at optimized conditions (room temperature, 45 min, 0.1 mg bleomycin for 2-10mCi CuCl2) with radiochemical purity over 98% determined by HPLC and RTLC. [Cu]BLM was administered into the normal and tumor bearing rodents up to 210 minutes followed by biodistribution and co incidence imaging studies. A significant tumor/non tumor accumulation was observed either by animal sacrification or imaging method. [Cu]BLM can be a potential PET radiotracer for tumor imaging.