Preclinical Animal Models for Cancer Research and Drug Discovery

Cancer has a complex biology and has been characterized by several hallmarks during its multistep progression such as sustaining proliferation, evading growth suppressors, resisting cell death, stimulating angiogenesis, activation of invasion and metastasis, etc. There is an increased understanding of complex biology of cancer in the past few decades; still this disease remains the primary cause of death in developed and developing countries all over the globe.