Aluminum bone content in dialysis osteodystrophy with secondary hyperparathyroidism.

To assess whether parathyroid hormone has any effect on bone aluminium accumulation, we evaluated the relationship between bone quantitiative histomorphometry and bone Al content in 25 dialysis patients with clinical features of secondary hyperparathyroidism. By means of bone biopsy, patients were classified as showing predominant hyperparathyroidism in 17 cases and mixed lesions in 8. The Al burden was low, judging from the dialysate Al and the oral Al assumption. Bone Al content and serum Al levels were higher than normal in both groups, particularly so in the patients with predominant hyperparathyroidism