Drug resistance analysis of Gram-negative bacillus with lower respiratory tract infection.

OBJECTIVE To study the antimicrobial resistance of Gram-negative bacilli isolated and their drug-resistant tendency in patients with lower respiratory tract infection.METHODS The bacterial distribution of Gram-negative bacilli was determined using conventional bacterial culture.The resistance rates of 282 Gram-negative bacilli strains were determined by K-B method.RESULTS The Pseudomonas aeruginosa,Klebsiella pneumoniae,and Acinetobactor baumannii,were the top three pathogens.Their detection rate was 23.76%,15.96% and 12.76%,respectively.The detection rate of extended spectrum beta lactamases(ESBLs) producers in K.pneumoniae and Escherichia coli were 35.56 % and 51.85%,respectively.Except for Haemophilus influenzae,the other Gram-negative bacilli were resistant to the routine drugs in different degrees.The resistance rate of A.baumannii to cephalosporins and suefamethoxazole/trimethoprim(cotrimoxazole) was more than 50.00%,the resistant rates of Gram-negative bacilli to the enzyme inhibitors drug containing such as piperacillin/tazobactam,and cefoperazone/sulbactam against were lower than 35.82%,but to amikacin was lower than 26.09%,so it could used for clinical therapy.CONCLUSIONS It is very necessary to monitor pathogens to provide the scientific evidence for clinical usage of the antibiotics.