ANTICANCER POTENCY OF HOLLY MANGROVE LEAF (Acanthus ilicifolius) METHANOL EXTRACT WITH TAURINE BY IN VITRO TEST IN CELL CULTURE OF HELA CERVICAL CANCER

. Holly mangrove which much abundance in mangrove area, known by locals as anti-inflammatory. This study was conducted to evaluate of its action as anticancer in vitro. Holly mangrove leaf methanol extraction was proven through cytotoxic and antiproliferation tests by MTT method (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) on HeLa cervical cancer cell culture. The results indicates that the extraction had a cytotoxic activity with IC50 values are 206 ppm, while the doubling time value in the antiproliferation test indicated much higher values than the control (72.19 hours). Keywords : holly mangrove leaf, cytotoxic, antiproliferation, and HeLa cell.