Medical/Legal Concerns in the Management of Patients from Lynch Syndromes Kindreds

The management of patients affected or at risk for the Lynch Syndromes must focus upon its natural history, early age of onset, predilection for the proximal Colon, excess of synchronous and metachronous Colon cancer, and autosomal dominant mode of inheritance (Lynch Syndrome I). In addition, predisposition to carcinoma of the endometrium, ovary, stomach, pancreas, and other anatomic sites are integral features of the Lynch Syndrome II counterpart [Lynch H.T., 1985, 1988, 1988a]. The absence of biomarkers for the genotype and/ or premonitory signs, such as multiple colonic adenomatous polyps, as occurs in the familial adenomatous polyposis (FAP) syndrome, makes the job of the diagnostician a vexing one [Cristofaro G., 1988, 1989].