TLR9 and IL23R Genetic Interaction Modulates Crohn'S Disease Susceptibility

recognition of pathogen microorganisms, are belived to be associated with IBD pathogenesis. The aim of our study is to investigate the involvement of bactericidal permeability increasing protein (BPI) gene polymorphism (BPI Lys216Glu) in a large group of Turkish IBD patients. A total of 528 IBD patients (224 Crohn's Disease and 304 Ulcerative Colitis), and 339 healthy controls were included to the study. After statistical analyses, BPI Lys216Glu polymorphism was found to be associated with both Crohn's Disease and Ulcerative Colitis (p= 0,0001). GG genotype was found significantly lower in patients using steroid and having steroid dependence (respectively, p= 0,0127, OR: 0,80 %95 CI: 0,680,94; p= 0,0286, OR: 0,75 %95 CI: 0,660,86). Otherwise, we could not find an association between subphenotypes of IBD. Distribution and Comparison of Genotypes and Allels