Лейкоцитарные и сывороточные факторы риска у больных облитерирующим атеросклерозом артерий нижних конечностей

The research was conducted devoted to the study of additional serum and leukocyte new risk factors in patients with obliterating atherosclerosis of lower limb arteries (OALA). All patients underwent the study of the concentration of C-reactive protein (CRP), lipoprotein (a) (LP (a)), defensins alpha(1-3), the factor of Villebranda (FV), NT fragment of precursor brain natriuretic peptide (NT-proBNP), factor VII clotting (VIIf) in serum and leukocyte supernatant and values lipid-releasing leukocytes ability (LRLA). We found that for patients with OALA characterized by a higher concentration of LP (a) and CRP in the leukocyte supernatant than in other groups of observations, which indicates that reparative and inflammatory orientation occurring in these patients processes. At patients with OALA with signs of unstable plaques and proximal type of arterial lesions in the leukocyte supernatant usually revealed CRP, and when the distal type of lesion of the vascular bed defensin alpha (1-3), which explains the predominant mechanisms of inflammatory response (infectious and noninfectious type) in different clinical situations. Value LRLA has a direct moderate strength relationship with the ankle-brachial index, which indicates the value of this parameter as a marker of the severity of atherosclerotic lesions.