Activation of diverse signalling pathways by oncogenic PIK3CA mutations
2014
Mutations in PIK3CA, a catalytic subunit of PI3 kinase, are linked to deregulation of Akt-mTOR signalling in many cancers. Here, using a SILAC-based quantitative proteomic approach, the authors discover six new AKT1 substrates, including the actin regulator cortactin.
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