An Expeditious Approach to Tetrazoles from AmidesUtilizing Phosphorazidates
2020
A novel method was developed for
the synthesis of tetrazoles from
amides utilizing diphenyl phosphorazidate or bis(p-nitrophenyl) phosphorazidate as both the activator of amide–oxygen
for elimination and azide source. Various amides were converted into
the corresponding tetrazoles in good yields. This synthetic method
allows to prepare 1,5-disubstituted and 5-substituted 1H-tetrazoles from various amides without the use of toxic or explosive
reagents.
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